Different medicinal herbs and plants extracts have potent hepatoprotective activity in various animal models. Hepatoprotective activity of aqueous and ethanolic bixa orellana l. Antioxidant activity of spilanthes acmella extracts. In the in vivo studies, the ccl4 treated control rats showed a significant alteration in the levels of antioxidant and hepatoprotective. There is area for further study to characterize the active principle responsible for the hepatoprotective activity of the plant. Pdf a search for hepatoprotective activity of fruit. Hepatoprotective activity of the extract of homalium. Hepatoprotective activity of water extracts from chaga medicinal mushroom, inonotus obliquus higher basidiomycetes against tertbutyl hydroperoxideinduced oxidative liver injury in primary cultured rat hepatocytes.
A number of studies have shown that the plant extracts having antioxidant activity protect against ccl4 hepatotoxicity by inhibiting lipid peroxidation and enhancing antioxidant enzyme activity shahjahan et al. The aim of the study is to investigate the hepatoprotective activity of melia. The strong antioxidant activity of this extract explains the significant. Original article, clinical report by journal of evolution of medical and dental sciences. Jun 19, 2018 the potential hepatoprotective activities of two lannea species were explored in vivo. This work screened the hepatoprotective and antioxidant activity of ethanol ers, and aqueous ars, extracts of leaves of raphanus sativus in carbon tetrachloride ccl4, model in rats. The liver damaging effect of ccl4 is explained by its ability to produce trichloromethyl free radicals and reactive oxygen species ros after being. Dec 17, 2019 the hepatoprotective impact of the extract of sp might be as a result of its free radical scavenging and antioxidant activities. A recent update on hepatoprotective potential of herbal plant. Plant extracts can be the best source of such antioxidants and mediate hepatoprotective activity. Pdf hepatoprotective activity of methanol extract of. Hepatoprotective activity of 50% ethanolic leaf extracts of parkinsonia aculeata was evaluated against carbon tetrachloride ccl 4induced hepatic damage in rats. The present study aimed to determine the hepatoprotective activity of a methanol extract of melastoma malabathricum leaves memm using two established rat models. Ten groups of rats n 6 were given a oncedaily administration of 10% dimethyl sulfoxide negative control, 200 mgkg silymarin positive control, or memm 50, 250, or 500 mgkg for 7 days followed by induction of.
The hepatoprotective activity of the plant may be attributed to the phenolic compounds, flavonoids, and saponins 6164. The extracts were subjected to antioxidant tests total reducing power and total phenolic content, and preliminary phytochemical. Potent free radical scavenging capacity of pongamia pinnata can be attributed to different flavones present in the extracts. Hepatoprotective activity of melia azedarach leaf extract. This may indicate that the plant extracts contain compounds, which can remove toxic metabolites following tbh induced toxicity. Ficus carica, hepatoprotective activity, carbontetra chloride, silymarin. Hepatoprotective activity of cinnamon ethanolic extract. So the plant may be useful in the management of free radical mediated diseases. Molecules free fulltext antioxidant and hepatoprotective. This hepatotoxic activity can be measured using sgot, sgpt and mda. Aqueous and alcoholic extracts of terminalia catappa were taken. A number of studies have shown that the plant extracts having antioxidant activity protect against ccl 4 hepatotoxicity by inhibiting lipid peroxidation and enhancing antioxidant enzyme activity 45, 42, 21, 24,46 and38. In vitro antioxidant and in vivo hepatoprotective activity of. Recent experience has shown that plant drugs are nontoxic, safe and even free from side effects 4.
The invitro antioxidant activity was estimated for different extracts on superoxide, hydroxyl and 1,1 diphenyl2picrylhydrazyl free radicals and the hepatoprotective activity of the. This present investigation was aimed to assess the hepatoprotective activity of aqueous and ethanol extract of pongamia pinnata leaves against acetaminopheninduced liver damage in albino rats. Hepatoprotective activity of capparis decidua aqueous and methanolic stems extracts against carbon tetrachloride induced liver histological damage in rats. The hepatoprotective and antioxidant activity of aqueous and methanolic extracts of pseudocedrela kotschyi stem bark was confirmed by biochemical, antioxidant and histopathological studies. In an attempt to further establish the pharmacological properties of bauhinia purpurea fabaceae, hepatoprotective potential of methanol extract of b. In india, numerous medicinal plants are used for the treatment of liver disorders. Aqueous extract of asparagus racemosus root aear was evaluated for its hepatoprotective activities in rats. Pdf medicinal plants possessed hepatoprotective activity. Pdf hepatoprotective activity of some plants extract. L leaves extracts against simvastatin induced hepatotoxicity. The hepatoprotective activity is probably due to the presence of flavonoids, phenolic compounds, polyphenols etc in all few herbal plants.
Hepatoprotective activity of ethanolic extract of salix subserrata. Hepatoprotective activity of methanolic extract of bauhinia. Parmar and others published hepatoprotective activity of some plants extract against paracetamol induced hepatotoxicity in wistar rats find, read and cite all the. Leaf extracts were given in the dose of 200 mgkg body weight for 7 days and toxicity was induced by paracetamol 2 gkg on day 5. Hepatoprotective and antioxidant activity of standardized. The hepatoprotective activity of methanol extract of aerial parts of canna indica l.
The present study was conducted to evaluate the hepatoprotective activity of methanolic extract of whole plant of pulicaria. Health, general albinism carbon tetrachloride usage liver liver diseases medical research medicine, experimental. The finding of the present study implied that the ethanolic extract of sp may be taken into account as a valuable substitute to adjust hepatotoxicity induced by apap. Antioxidant and hepatoprotective activity of methanolic and. Oxidative stress analytical chemistry free radical plant extract vital role. The present investigation is aimed to evaluate the hepatoprotective effects of citrus hystrix and citrus maxima red and white variety methanolic leaf extracts on paracetamol induced toxicity.
Hepatoprotective effect of aqueous extracts of some medicinal. Evaluation of the cytotoxic activity of extracts from medicinal plants used for the treatment of malaria in kagera and lindi regions, tanzania. Hepatoprotective and antioxidant activity of watercress. Medical plant extracts and natural compounds with a hepatoprotective effect against damage caused by antitubercular drugs. Because phenolic and flavonoid compounds are recognized as the bases of the antioxidant activity of plant extracts, we determined the phenolic and flavonoid content of vcfe. Thus the antioxidant activity of the ethanolic extract may be due to the presence of flavonoid and phenolic compounds. Hepatoprotective activity of the ethanolic extract of ficus. Hepatoprotective activity of some medicinal plants in sudan. Pdf evaluation of the cytotoxic activity of extracts. Pp hydroalcoholic leaf extract, a plant rich in antioxidant, on hepatic ischemiareperfusion ir injury. The extract at doses of 100, 200 and 300 mg kg1 body weight were administered orally once daily. Hepatoprotective activity of capparis decidua aqueous and. Hepatoprotective activity of water extracts from chaga.
The goal of the present study was to examine the antioxidant and hepatoprotective activity of some medicinal. Natural remedies from medicinal plants are considered to be effective and safe alternative treatment for liver injury. Hepatoprotective activity of methanol extract of melastoma. It was found that the antioxidant activity of the ethyl acetate extract of v. Silymarin as a standard drug for comparing the activity. Hepatoprotective activity was measured based on biochemical parameters. The highest antioxidant activity was found in ethyl acetate and nbutanol followed by dichloromethane, hexane, and aqueous extracts. The results obtained showed that these extracts possess significant hepatoprotective activity. Hepatoprotective activity of some indigenous plants.
Hepatoprotective effect of leaf extracts from citrus hystrix. The free radical mediated process has been implicated in the pathogenesis of different diseases. Hepatoprotective activity of flavonoids is due to their ability to scavenge free radicals. Hepatoprotective activity of some plants extract against paracetamol induced hepatotoxicity in wistar rats. The present study was carried out to screen and evaluate the hepatoprotective activity of leaf extracts of aegle marmelos l. Hepatoprotective and antioxidant effect of stem barks. Historically, botanicals have been reported to possess good antioxidative activities as demonstrated by their free radical scavenging property rendering their usage in liver protection. Pdf hepatoprotective activity of methanolic extract of.
The liver performs a vital role in metabolism, secretion, storage, and detoxification of endogenous and exogenous substances. In this study, we describe the potential use of map, a standardized blend comprising three extracts from myristica fragrans, astragalus membranaceus, and. Hepatoprotective plantsandrographis lineata neeshepatoprotective effect of andrographis lineata acanthaceae extracts in ccl4. Antimicrobial activity of some plant extracts having hepatoprotective effects ammara hassan, salma rahman, farah deeba and shahid mahmud applied chemistry research centre, pcsir labs. Srinivasa rao, mohammed fazil ahmed and mohammed ibrahim abstract the aim of the study is to investigate the hepatoprotective activity of melia azedarach leaves extracts against simvastatin induced hepatotoxicity. Hepatoprotective activities of ethanolic and aqueous extracts of a. About 600 commercial herbal formulations with hepatoprotective activity are being sold all over the world. Hepatoprotective activity of melia azedarach leaf extract against simvastatin induced hepatotoxicity a. Antioxidant and hepatoprotective activity of garlic chives.
Antimicrobial activity of some plant extracts having. Hepatoprotective and antioxidant activity of methanol extract. Tanninrich extracts from lannea stuhlmannii and lannea. Apr 23, 2008 the present study was carried out to evaluate ficus glomerata extracts for antioxidant and hepatoprotective properties. Carbon tetrachloride, hepatoprotection, paracetamol, psidium guajava, thioacetamide liver diseases, such as jaundice, cirrhosis and fatty liver are very common worldwide. Investigations on hepatoprotective activity of leaf extracts. A lot of herbal plants and polyherbal formulations are used for the treatment of liver diseases. Pdf hepatoprotective activity of some plants extract against. Oxidative stress and free radicals enhance the severity of hepatic damage, which can be overcome by the antioxidant mechanism. Hepatoprotective activity of the ethanolic extract of ficus caricalinn.
The methanol extracts of plant materials of some plants like casuarina equisetifolia, cajanus cajan, glycosmis pentaphylla, bixa orellana, argemone mexicana, physalis minima, caesalpinia bonduc, belonging to the different family were studied for. Hepatoprotective activity of fruit extracts of phyllanthus. It should be noted that the hepatoprotective effects of wc extract is probably because of its antioxidant activity as a free radical scavenger. Hepatoprotective activity of an herbal composition, map, a. The basic plant material of melia azedarach linn used for. The extracts exhibited significant antioxidant property as evident by the trolox values and effective scavenging of dpph. Its hepatoprotective activity is attributed to its antioxidant properties. Hepatoprotective and antioxidant activity of hydroalcoholic.
A recent update on hepatoprotective potential of herbal plant mohammad irfan ali1 and manoj kumar2 1school of sciences, suresh gyan vihar university, jaipur302017, rajasthan, india 2marine biotechnology laboratory, department of botany, university of delhi, north campus, india corresponding authoremail. Hepatoprotective activity of some medicinal plants in sudan hindawi. Hepatoprotective activity of fruit extracts of phyllanthus acidus linn. The present study was designed to assess the hepatoprotective activity and cytotoxicity of methanolic and water extracts of f. A search for hepatoprotective activity of fruit extract of mangifera indica l. Vanillin, a phenolic aldehyde has been reported to possess antioxidant and free radical scavenging ability kamat et al. There are many plants and traditional formulations available to treat the liver diseases 5, 6. Keeping this view in the mind, bark extracts of terminalia catappa was selected for to evaluate the hepatoprotective activity. Hepatoprotective effect of leaf extracts of parkinsonia.
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